The van came with the Michelin LX4's which wore out at 40k. Was very happy with the feel of the Michelins in all conditions except for the snow in which they were dreadful. I use Blizzaks in the winter on dedicated wheels. Purchased the RT43's to replace the LX4's thinking that spring was here and wouldn't you know it, we get hit with a snow/ice storm. The RT43's were quite good in the snow/ice on brand new tires although I prefer a dedicated snow tire for the van.
For regular driving the RT43's are close to the Michelins but I prefer the feel of the Michelins. However, given the price differential between a new set of LX4's (or Defenders) and the all around capability of the RT43's plus favorable reviews, these tires get high marks and were worth a try. If they last 50K for this van which has a reputation for eating up tires, it is a no brainer. If they don't last, back to the Michelins.
As far as fuel economy is concerned, I think that the Michelins are better but time will tell.