I've now driven these tires across almost every hwy in Southern CO, as well as across KS, MO, AR, TX, and NM. Temps have ranged everywhere from -25 up to 115 and not a single problem. They aren't the quietest tire I've ever used, but the ride quality is very good and they are very predictable corning. My MPG has actually improved by 1-1.5 as they've worn down a bit.
On wet roads w/o standing water, they perform admirably, but I have noticed some splashiness when hitting shallow puddles and such. It's never alarming, just noticeable. Tread wear has been perfectly even with no flat spots developing.
In winter, I've made it over every road surface attempted without a hairy moment. That includes the like of Red Mountain Pass, Wolf Creek Pass, Monarch, and even up over Rabbit Ears. The only issues have been with heavy, packed snow in parking lots, and that's as much to do with my car as the tire itself.
Overall, I would HIGHLY recommend this tire. It's performed beyond my expectations.
My previous tires were the Bridgestone Dueler's as comparison, and they were just slightly better in the dry, but the Conti's have been MUCH better in Rain/Snow.