Many drivers are uncertain whether they can put non-run-flat tires on wheels that originally came with run-flat tires. The short answer: yes.
Run-flat tires and regular tires that are the same numeric size will have the same physical dimensions, and can fit properly on the same wheels. The only difference with run-flat wheels is they usually have an extra hump behind the bead seat. This hump would help keep the run-flat tire in its proper place on the wheel while driving without air pressure. It does not affect the performance or compatibility of the non-run-flat tire.
A few words of caution: If you are changing to non-run-flat tires from run-flat tires, make sure you have a plan for what you will do in the event that you do have a flat tire. An air compressor and sealant can easily seal a minor puncture. A plug kit can also be useful for a temporary repair. You should have some sort of roadside assistance that you can call if you have a larger puncture. Some cars may have space to store a spare tire, though some cars with run-flats do not have any convenient location for the tire.
If a spare tire is an option, remember that you should maneuver more cautiously when your vehicle is equipped with a Temporary/Compact Spare tire and three standard tires. Any differences in tire traction can reduce vehicle handling and increase braking distances, especially in emergency situations.
Whether you're looking for a set of non-run-flat or run-flat tires, shop by vehicle and view all options available for your application.